Prof Andrew Bush MD a , Sejal Saglani MD a. The Lancet, Volume 376, Issue 9743, Pages 814 - 825, 4 September 2010
Children who are referred to specialist care with asthma that does not respond to treatment (problematic severe asthma) are a heterogeneous group, with substantial morbidity.
The evidence base for management is sparse, and is mostly based on data from studies in children with mild and moderate asthma and on extrapolation of data from studies in adults with severe asthma. In many children with severe asthma, the diagnosis is wrong or adherence to treatment is poor.
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