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2011 Feb 16 - Lancet Comment: Cell-culture-derived influenza vaccine production

2011 Feb 16 - Lancet Comment: Cell-culture-derived influenza vaccine production

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W Paul Glezen. The Lancet, Early Online Publication, 16 February 2011

In The Lancet , Noel Barrett and colleagues 1 report a randomised placebo-controlled trial of a trivalent influenza vaccine produced with viruses grown in Vero-cell culture. The vaccine proved to be highly efficacious in this field trial of more than 7000 adults aged 18—49 years. The results compared favourably with those from previous trials of the traditional egg-grown virus antigens in the same age group. 2

The investigators pointed out several advantages of the tissue-culture substrate over those ...

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